Origin of a "bridge" intron in the gene for a two-domain globin.

  title={Origin of a "bridge" intron in the gene for a two-domain globin.},
  author={Yasushi Naito and Claire K Riggs and Thomas L. Vandergon and Austen F. Riggs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={88 15},
Red cells of the clam Barbatia reeveana express two hemoglobins, one composed of 16- to 17-kDa chains and the other of 35-kDa chains. The nucleotide sequence of the cDNA encoding the 35-kDa chain shows that the polypeptide has two very similar heme-binding domains, which are joined without use of an additional bridging sequence. Two novel introns occur in the gene for the two-domain globin: one, the "precoding" intron, is located two bases 5' from the start codon, and the other, a "bridge… CONTINUE READING

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