Origin of Human Chromosome 21 and its Consequences: a 50-million-year-old Story

@article{Richard1998OriginOH,
  title={Origin of Human Chromosome 21 and its Consequences: a 50-million-year-old Story},
  author={Florence Anne Richard and Bernard Dutrillaux},
  journal={Chromosome Research},
  year={1998},
  volume={6},
  pages={263-268}
}
Great apes (Pongidae) possess a chromosome similar to human chromosome 21 (HSA21), whose trisomy was described in both chimpanzee and orangutan. Having studied more than 200 mammalian species by chromosome banding techniques and reconstructed Primates phylogeny, we reinvestigated, using fluorescence in situ hybridization, primate and non-primate mammals that we considered to possess a karyotype representative of their taxonomic group. DNA sequences from HSA21 and human chromosome 3 (HSA3) are… CONTINUE READING
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Comparative Genomics

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