Origin of GABAergic neurons in the human neocortex

@article{Letinic2002OriginOG,
  title={Origin of GABAergic neurons in the human neocortex},
  author={Kresimir Letinic and Roberto Zoncu and Pasko Rakic},
  journal={Nature},
  year={2002},
  volume={417},
  pages={645-649}
}
The mammalian neocortex contains two major classes of neurons, projection and local circuit neurons. Projection neurons contain the excitatory neurotransmitter glutamate, while local circuit neurons are inhibitory, containing GABA. The complex function of neocortical circuitry depends on the number and diversity of GABAergic (γ-aminobutyric-acid-releasing) local circuit neurons. Using retroviral labelling in organotypic slice cultures of the embryonic human forebrain, we demonstrate the… 
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