Origin of Cancer Stem Cells: The Role of Self-Renewal and Differentiation

  title={Origin of Cancer Stem Cells: The Role of Self-Renewal and Differentiation},
  author={Xiong-Zhi Wu},
  journal={Annals of Surgical Oncology},
Self-renewal and differentiation potential is the feature of stem cells. Differentiation is usually considered to be a one-way process of specialization as cells develop the functions of their ultimate fate and lose their immature characteristics, such as self-renewal. Progenitor cells, the products of stem cells losing the activity of self-renewal, could differentiate to mature cells, which have the feature of differentiation and lose the activity of self-renewal.The roles for cancer stem… CONTINUE READING

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