Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

@article{Holt1994OriginAS,
  title={Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.},
  author={Patrick G. Holt and Shona Haining and Delia Jane Nelson and Jonathon D. Sedgwick},
  journal={Journal of immunology},
  year={1994},
  volume={153 1},
  pages={256-61}
}
Recent studies have identified a contiguous network of class II MHC-bearing dendritic cells (DC) in the airway epithelium of several species, including humans. This network seems comparable to the epidermal Langerhans cell population, comprising up to 700 DC per mm2 of airway epithelium. Moreover, it accounts for virtually all local immunostaining for class II MHC, suggesting an important role in surveillance for inhaled Ag. This study examines the turnover of these airway DC using a radiation… CONTINUE READING

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