Origin and propagation of electrical slow waves in circular muscle of canine proximal colon.

@article{Smith1987OriginAP,
  title={Origin and propagation of electrical slow waves in circular muscle of canine proximal colon.},
  author={Terence Keith Smith and J. B. Reed and Kenton M. Sanders},
  journal={The American journal of physiology},
  year={1987},
  volume={252 2 Pt 1},
  pages={C215-24}
}
Experiments to determine the site of slow-wave origin and the mechanism of propagation were performed on muscles of the canine proximal colon. Cells along the submucosal border of the circular layer had resting membrane potentials (RMP) averaging -78 mV, and slow waves, 40 mV in amplitude. The RMP of cells through the thickness of the circular layer decreased exponentially with distance from the submucosal border, such that RMPs of circular cells at the myenteric border were only -43 mV. Slow… CONTINUE READING
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