Origin and molecular evolution of receptor tyrosine kinases with immunoglobulin-like domains.

@article{Grassot2006OriginAM,
  title={Origin and molecular evolution of receptor tyrosine kinases with immunoglobulin-like domains.},
  author={Julien Grassot and Manolo Gouy and Guy Perri{\`e}re and Guy Mouchiroud},
  journal={Molecular biology and evolution},
  year={2006},
  volume={23 6},
  pages={1232-41}
}
Receptor tyrosine kinases (RTKs) are involved in the control of fundamental cellular processes in metazoans. In vertebrates, RTK could be grouped in distinct classes based on the nature of their cognate ligand and modular composition of their extracellular domain. RTK with immunoglobulin-like domains (IG-like RTK) encompass several RTK classes and have been found in early metazoans, including sponges. Evolution of IG-like RTK is characterized by extended molecular and functional diversification… CONTINUE READING
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