Origin and function of tumor stroma fibroblasts.

  title={Origin and function of tumor stroma fibroblasts.},
  author={Georgia Xouri and S h e d D. Christian},
  journal={Seminars in cell & developmental biology},
  volume={21 1},
Tumor development is critically dependent on the formation of a supporting stroma consisting of neovasculature, inflammatory cells and activated fibroblasts. Activated fibroblasts present a heterogeneous cell population not only in regard to the expression of marker molecules but also to their origin and molecular signaling properties. The plasticity of this cell type is pointed out by the multiple transdifferentiation events that lead to the generation of activated fibroblasts which can arise… CONTINUE READING

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