Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.


A crucial question in mammalian development is how cells of the early embryo differentiate into distinct cell types. The first decision is taken when cells undertake waves of asymmetric division that generate one daughter on the inside and one on the outside of the embryo. After this division, some cells on the inside remain pluripotent and give rise to the… (More)
DOI: 10.1073/pnas.0915063107


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