Origin and evolution of the ligand-binding ability of nuclear receptors

@article{Markov2011OriginAE,
  title={Origin and evolution of the ligand-binding ability of nuclear receptors},
  author={Gabriel V. Markov and Vincent Laudet},
  journal={Molecular and Cellular Endocrinology},
  year={2011},
  volume={334},
  pages={21-30}
}
The origin of the ligand-binding ability of nuclear receptors is still a matter of discussion. Current opposing models are the early evolution of an ancestral receptor that would bind a specific ligand with high affinity and the early evolution of an ancestral orphan that was a constitutive transcription factor. Here we review the arguments in favour or against these two hypotheses, and we discuss an alternative possibility that the ancestor was a ligand sensor, which would be able to explain… Expand

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