Origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009

  title={Origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009},
  author={Denham Harman},
  • D. Harman
  • Published 24 May 2009
  • Biology, Medicine
  • Biogerontology
Aging is the progressive accumulation in an organism of diverse, deleterious changes with time that increase the chance of disease and death. The basic chemical process underlying aging was first advanced by the free radical theory of aging (FRTA) in 1954: the reaction of active free radicals, normally produced in the organisms, with cellular constituents initiates the changes associated with aging. The involvement of free radicals in aging is related to their key role in the origin and… 
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