Origin and evolution of the chicken leukocyte receptor complex.

  title={Origin and evolution of the chicken leukocyte receptor complex.},
  author={Nikolas Nikolaidis and Izabela Makalowska and Dimitra Chalkia and Wojciech Makalowski and Jan Klein and Masatoshi Nei},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 11},
In mammals, the cell surface receptors encoded by the leukocyte receptor complex (LRC) regulate the activity of T lymphocytes and B lymphocytes, as well as that of natural killer cells, and thus provide protection against pathogens and parasites. The chicken genome encodes many Ig-like receptors that are homologous to the LRC receptors. The chicken Ig-like receptor (CHIR) genes are members of a large monophyletic gene family and are organized into genomic clusters, which are in conserved… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 24 extracted citations


Publications referenced by this paper.
Showing 1-2 of 2 references

Molecular Evolution and Phylogenetics (Oxford

  • M. Nei, S. Kumar
  • 2000
1 Excerpt

Immunology (Blackwell Scientific, Oxford)

  • J. Klein, V. Hořejšı
  • 1997
1 Excerpt

Similar Papers

Loading similar papers…