Origin and evolution of the chicken leukocyte receptor complex.

@article{Nikolaidis2005OriginAE,
  title={Origin and evolution of the chicken leukocyte receptor complex.},
  author={Nikolas Nikolaidis and Izabela Makalowska and Dimitra Chalkia and Wojciech Makalowski and Jan Klein and Masatoshi Nei},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 11},
  pages={4057-62}
}
In mammals, the cell surface receptors encoded by the leukocyte receptor complex (LRC) regulate the activity of T lymphocytes and B lymphocytes, as well as that of natural killer cells, and thus provide protection against pathogens and parasites. The chicken genome encodes many Ig-like receptors that are homologous to the LRC receptors. The chicken Ig-like receptor (CHIR) genes are members of a large monophyletic gene family and are organized into genomic clusters, which are in conserved… CONTINUE READING

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