Origin and evolution of the Trk family of neurotrophic receptors

@article{BenitoGutirrez2006OriginAE,
  title={Origin and evolution of the Trk family of neurotrophic receptors},
  author={{\`E}lia Benito-Guti{\'e}rrez and Jordi Garcia-Fern{\'a}ndez and Joan X. Comella},
  journal={Molecular and Cellular Neuroscience},
  year={2006},
  volume={31},
  pages={179-192}
}
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55 Citations
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55 Citations

Tracing the Evolution and Function of the Trk Superfamily of Receptor Tyrosine Kinases
  • W. Sossin
  • Biology
    Brain, Behavior and Evolution
  • 2006
TLDR
The evolution of the Trk superfamily is traced and possible conserved functional roles are discussed, including a unifying theme of target recognition by growing axons, proposing that an important driving force for the divergence of receptors is the ease of divergence of their ligands.
Formation and Evolution of the Chordate Neurotrophin and Trk Receptor Genes
TLDR
It appears certain that the formation of the multi-gene copy neurotrophin and Trk receptor families at the stem of vertebrates has provided a foundation from which the various functions and pleiotropic effects produced by each of the four extant neurotrophins have evolved.
Molecular evolution of the neurotrophin family members and their Trk receptors.
Regulation and Kinase Activity of the Trk Family of Receptor Tyrosine Kinases
TLDR
Light is shed on potential differences between TrkA and TrkB signaling, as well as providing a quantitative understanding of Trk TKD activation, which is useful for effective and selective inhibitor design.
Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system
Neurotrophins and their Trk‐receptors in the cerebellum of zebrafish
TLDR
The occurrence of NTs and Trk‐receptors suggests that they could have a synergistic action in the cerebellum of zebrafish.
Neurotrophin, p75, and Trk Signaling Module in the Developing Nervous System of the Marine Annelid Platynereis dumerilii
TLDR
Annelid data corroborate the hypothesis that the neurotrophic signaling and its involvement in shaping neural networks predate the protostome-deuterostome split and were present in bilaterian ancestors.
The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish
TLDR
This review updates current knowledge about the distribution and functions of the BDNF-TrkB system in the sensory organs of zebrafish and identifies two categories of receptors: p75NTR and Trk.
Expression of the neurotrophic tyrosine kinase receptors, ntrk1 and ntrk2a, precedes expression of other ntrk genes in embryonic zebrafish
TLDR
Ntrk1 and ntrk2a are the initial neurotrophic tyrosine kinase receptors expressed in sensory neurons during the development of the zebrafish body, and this work is the first to establish expression patterns of ngfrb during early zebra fish development.
A comprehensive analysis of neurotrophins and neurotrophin tyrosine kinase receptors expression during development of zebrafish
TLDR
This study unveils new expression domains in the developing embryo, confirms those previously known, and shows that ntf and ntrk genes have different degrees of cell‐ and tissue‐type specificity.
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References

SHOWING 1-10 OF 118 REFERENCES
Early evolutionary origin of the neurotrophin receptor family
TLDR
A molluscan Trk receptor from the snail Lymnaea stagnalis is described, supporting an early evolutionary origin of the Trk family as neuronal receptor tyrosine kinases and suggesting that Trk signalling mechanisms may be highly conserved between vertebrates and invertebrates.
Neurotrophic activities of trk receptors conserved over 600 million years of evolution.
TLDR
It is shown that the Ltrk gene conserves a similar exon/intron order as mammalian trk genes in the region encoding defined extracellular motifs, including one exon encoding a putative variant immunoglobulin-like domain.
TrkA and TrkC neurotrophin receptor-like proteins in the lizard gut
TLDR
These results demonstrate for the first time the occurrence of Trk-like proteins in non-neuronal tissues of reptilians and provide further evidence for the evolutionary preservation of the molecular mass and cell distribution of TrK neurotrophin receptor- like proteins in the gut of vertebrates.
TrkA Amino Acids Controlling Specificity for Nerve Growth Factor*
TLDR
A minimum set of residues in the human TrkC second immunoglobulin-like domain, which does not bind nerve growth factor (NGF), were substituted with those from human TrKA and the resulting Trk variant recruited binding of NGF equivalent to TrkA, maintained neurotrophin-3 binding equivalent totrkC, and also bound brain-derived neurotrophins, although with lower affinity compared with TrkB.
Evolution of the vertebrate neurotrophin and Trk receptor gene families
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
TLDR
In situ hybridization analysis of 14 and 18 day old mouse embryos indicates thattrkB transcripts are localized in the central (CNS) and peripheral (PNS) nervous systems, including brain, spinal cord, spinal and cranial ganglia, paravertebral trunk of the sympathetic nervous system and various innervation pathways, suggesting that trkB may code for a novel cell surface receptor involved in neurogenesis.
Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview.
  • R. Lindsay
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1996
TLDR
Much broader effects of neurotrophins on sensory neurons are now evident, including paracrine and autocrine actions on neuroblast proliferation, phenotypic differentiation, and survival and regeneration in the adult.
Five Trk receptors in the zebrafish.
TLDR
The degree of sequence variation and expression differences within the family suggest that each of the five zebrafish Trk receptors have a functionally distinct role, demonstrating that the vertebrate Trk family is larger than previously appreciated.
Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases.
TLDR
It is suggested that Dror may encode a neurotrophic receptor that functions during early stages of neural development in Drosophila, which is expressed specifically in the developing nervous system.
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