Origin and evolution of self-consumption: autophagy.


While misfolded and short-lived proteins are degraded in proteasomes located in the nucleus and cytoplasm, the degradation of organelles and long-lived proteins in the lysosome occurs by the process of autophagy. Central and necessary to the autophagic process are two conserved ubiquitin-like conjugation machineries. These conjugation machineries appear to… (More)


Cite this paper

@article{Hughes2007OriginAE, title={Origin and evolution of self-consumption: autophagy.}, author={Timothy R. Hughes and Tor Erik Rusten}, journal={Advances in experimental medicine and biology}, year={2007}, volume={607}, pages={111-8} }