Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications?

@article{Gritsun2007OriginAE,
  title={Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications?},
  author={Tamara Sergeevna Gritsun and Ernest Andrew Gould},
  journal={Virology},
  year={2007},
  volume={366 1},
  pages={8-15}
}
Flavivirus replication is mediated by interactions between complementary ssRNA sequences of the 5'- and 3'-termini that form dsRNA cyclisation stems or panhandles, varying in length, sequence and specific location in the mosquito-borne, tick-borne, non-vectored and non-classified flaviviruses. In this manuscript we manually aligned the flavivirus 5'UTRs and adjacent capsid genes and revealed significantly more homology than has hitherto been identified. Analysis of the alignments revealed that… CONTINUE READING