Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487Lys.

  title={Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487Lys.},
  author={Huai-Rong Luo and G Wu and Andrew J. Pakstis and Li Tong and Hiroki Oota and Kenneth K. Kidd and Yaping Zhang},
  volume={435 1-2},
The East Asian respond with a marked facial flushing and mild to moderate symptoms of intoxication after drinking the amounts of alcohol that has no detectable effect on European. The alcohol sensitivity in Orientals is due to a delayed oxidation of acetaldehyde by an atypical aldehyde dehydrogenase ALDH2487Lys, which is resulted from a structural mutation in gene ALDH2. The atypical ALDH2487Lys allele has been associated with various phenotypic statuses, such as protective against alcohol… CONTINUE READING


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