Origin and differentiation of human and murine stroma.

  title={Origin and differentiation of human and murine stroma.},
  author={James E Dennis and Pierre Charbord},
  journal={Stem cells},
  volume={20 3},
Stromal cells generated in long-term cultures appear to follow a vascular smooth muscle differentiation pathway. Such a pathway, comprising several steps hallmarked by the expression of cytoskeletal and extracellular matrix markers, is found not only for bone marrow stromal cells, but also for stromal cells generated from the different developmental sites of hematopoiesis (yolk sac, aorta-gonad-mesonephros region, fetal liver, and spleen). Factors responsible for this differentiation pathway… CONTINUE READING