Origin, originality, functions, subversions and molecular signalling of macropinocytosis.

  title={Origin, originality, functions, subversions and molecular signalling of macropinocytosis.},
  author={Mustapha Amyere and Marcel Mettlen and Patrick Van der Smissen and Anna Platek and Bernard Payrastre and Alex Veithen and Pierre J. Courtoy},
  journal={International journal of medical microbiology : IJMM},
  volume={291 6-7},
Macropinocytosis refers to the formation of primary large endocytic vesicles of irregular size and shape, generated by actin-driven evaginations of the plasma membrane, whereby cells avidly incorporate extracellular fluid. Macropinosomes resemble "empty" phagosomes and show no difference with the "spacious phagosomes" triggered by the enteropathogenic bacteria Salmonella and Shigella. Macropinosomes may fuse with lysosomes or regurgitate their content back to the extracellular space. In… CONTINUE READING


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