Origin, genetic diversity, and genome structure of the domestic dog

@article{Wayne1999OriginGD,
  title={Origin, genetic diversity, and genome structure of the domestic dog},
  author={Robert K. Wayne and Elaine A. Ostrander},
  journal={BioEssays},
  year={1999},
  volume={21}
}
Comparative analysis of mammalian genomes provides important insight into the structure and function of genes. However, the comparative analysis of gene sequences from individuals of the same and different species also provides insight into the evolution of genes, populations, and species. We exemplify these two uses of genomic information. First, we document the evolutionary relationships of the domestic dog to other carnivores by using a variety of DNA‐based information. A phylogenetic… 

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References

SHOWING 1-10 OF 62 REFERENCES

Phylogenetic relationships, evolution, and genetic diversity of the domestic dog.

The results do not support a New World domestication of dogs nor a close association of the Xoloitzcuintli with other hair-less breeds of dogs, but mitochondrial DNA analysis suggests a more ancient origin of dogs than has been indicated by the fossil record.

Anchored reference loci for comparative genome mapping in mammals

A list of 321 reference anchor loci suitable for comparative gene mapping in mammals and other vertebrate classes is proposed and it is believed that the map may provide the basis for a unified approach to comparative analysis of mammalian species genomes.

Molecular evolution of the dog family.

  • R. Wayne
  • Biology, Environmental Science
    Trends in genetics : TIG
  • 1993

Molecular systematics of the Canidae.

A combined analysis of the mtDNA data and published morphological data provides unexpected support for a monophyletic South American canidae clade, although the homogeneity partition tests indicate significant heterogeneity between the two data sets.

A whole-genome radiation hybrid map of the dog genome.

A whole genome radiation hybrid map of the canine genome was constructed by typing 400 markers, including 218 genes and 182 microsatellites, on a panel of 126 radiation hybrid cell lines, and should prove a powerful tool for localizing and identifiying genes implicated in pathological and phenotypical traits.

Multiple and ancient origins of the domestic dog.

Sequences from both dogs and wolves showed considerable diversity and supported the hypothesis that wolves were the ancestors of dogs, suggesting that dogs originated more than 100,000 years before the present.

Patterns of differentiation and hybridization in North American wolflike canids, revealed by analysis of microsatellite loci.

It is demonstrated that wolves and coyotes do not show a pattern of genetic differentiation by distance, and gray wolves show significant subdivision that may be either due to drift in past Ice Age refugia populations or a result of other causes.

Gene localization and syntenic mapping by FISH in the dog.

To begin development of a canine gene map and to define syntenic regions between the canine and human genomes, the technique of fluorescence in situ hybridization (FISH) was adapted to localize

Comparative genomics: lessons from cats.

Identification and characterization of dinucleotide repeat (CA)n markers for genetic mapping in dog.

A large block of simple sequence repeat (SSR) polymorphisms for theDog genome has been isolated and characterized, and a comprehensive system of nomenclature for the dog genome is suggested.
...