Origin, genetic diversity, and genome structure of the domestic dog

  title={Origin, genetic diversity, and genome structure of the domestic dog},
  author={Robert K. Wayne and Elaine A. Ostrander},
Comparative analysis of mammalian genomes provides important insight into the structure and function of genes. However, the comparative analysis of gene sequences from individuals of the same and different species also provides insight into the evolution of genes, populations, and species. We exemplify these two uses of genomic information. First, we document the evolutionary relationships of the domestic dog to other carnivores by using a variety of DNA‐based information. A phylogenetic… 

Origins of the Domestic Dog and the Rich Potential for Gene Mapping

Research into causes of diseases in dogs is relevant to humans and other species; comparative genomics is being used to transfer genetic information to them, including some studies on morphological and behavioral phenotypes.

Companion Animal Genetics

The genome projects of the cat, the dog, and the horse have developed similar resources to those found in the human and mouse genome projects, including, radiation hybrid panels, chromosome painting probes, BAC libraries, and single tandem repeats markers, STRs.

Insights into morphology and disease from the dog genome project.

Man's best friend is discussed in the context of a genetic model to understand paradigms of heritable phenotypes, both desirable and disadvantageous.

Genetic characterization, at the mitochondrial and nuclear DNA levels, of five Canary Island dog breeds.

Although mtDNA haplotypes showed poor breed discriminating power, autosomal markers allowed a clear clustering of each single population and it is expected that these results will help to make the population histories of island dog breeds clearer.

Comparative cytogenetic analysis of sex chromosomes in several Canidae species using zoo-FISH.

The results show the presence of homologous synteny covering the entire structures of the X and the Y chromosomes, which suggests that sex chromosomes are conserved in the Canidae family.

Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes

This work suggests that the complex karyotype rearrangements associated with speciation of the Canidae reflect unstable chromosome regions described by the fragile breakage model and provides evidence that these breakpoints are also recurrently associated with spontaneous canine cancers.

Mitochondrial DNA Analysis of the Domestic Dog: Control Region Variation Within and Among Breeds

This reference data set has been compiled and validated against the published dog genetic literature with an aim to aid forensic investigations that seek to incorporate mtDNA sequences and SNPs from trace evidence such as dog hair.

Molecular origins of rapid and continuous morphological evolution

  • J. FondonH. Garner
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
A comparative genomic study of repetitive elements in developmental genes of 92 breeds of dogs finds evidence for selection for divergence at coding repeat loci in the form of both elevated purity and extensive length polymorphism among different breeds.

Basenji Origin and Migration: Domestication and Genetic History

The Wolf as the Basenji’s ancestor Charles Darwin thought that the diversity of the dog suggested it originated from two or more wild canine species, but modern studies suggest that domestic dogs descended from at least 5 female wolf lineages.



Phylogenetic relationships, evolution, and genetic diversity of the domestic dog.

The results do not support a New World domestication of dogs nor a close association of the Xoloitzcuintli with other hair-less breeds of dogs, but mitochondrial DNA analysis suggests a more ancient origin of dogs than has been indicated by the fossil record.

Anchored reference loci for comparative genome mapping in mammals

A list of 321 reference anchor loci suitable for comparative gene mapping in mammals and other vertebrate classes is proposed and it is believed that the map may provide the basis for a unified approach to comparative analysis of mammalian species genomes.

Molecular evolution of the dog family.

  • R. Wayne
  • Biology, Environmental Science
    Trends in genetics : TIG
  • 1993

Molecular systematics of the Canidae.

A combined analysis of the mtDNA data and published morphological data provides unexpected support for a monophyletic South American canidae clade, although the homogeneity partition tests indicate significant heterogeneity between the two data sets.

A whole-genome radiation hybrid map of the dog genome.

A whole genome radiation hybrid map of the canine genome was constructed by typing 400 markers, including 218 genes and 182 microsatellites, on a panel of 126 radiation hybrid cell lines, and should prove a powerful tool for localizing and identifiying genes implicated in pathological and phenotypical traits.

Multiple and ancient origins of the domestic dog.

Sequences from both dogs and wolves showed considerable diversity and supported the hypothesis that wolves were the ancestors of dogs, suggesting that dogs originated more than 100,000 years before the present.

Patterns of differentiation and hybridization in North American wolflike canids, revealed by analysis of microsatellite loci.

It is demonstrated that wolves and coyotes do not show a pattern of genetic differentiation by distance, and gray wolves show significant subdivision that may be either due to drift in past Ice Age refugia populations or a result of other causes.

Gene localization and syntenic mapping by FISH in the dog.

To begin development of a canine gene map and to define syntenic regions between the canine and human genomes, the technique of fluorescence in situ hybridization (FISH) was adapted to localize

Comparative genomics: lessons from cats.

Identification and characterization of dinucleotide repeat (CA)n markers for genetic mapping in dog.

A large block of simple sequence repeat (SSR) polymorphisms for theDog genome has been isolated and characterized, and a comprehensive system of nomenclature for the dog genome is suggested.