Orientational order of the lamellipodial actin network as demonstrated in living motile cells.

@article{Verkhovsky2003OrientationalOO,
  title={Orientational order of the lamellipodial actin network as demonstrated in living motile cells.},
  author={Alexander B. Verkhovsky and Oleg Y. Chaga and Sebastien Schaub and Tatyana M Svitkina and Jean-Jacques Meister and Gary G. Borisy},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 11},
  pages={
          4667-75
        }
}
Lamellipodia of crawling cells represent both the motor for cell advance and the primary building site for the actin cytoskeleton. The organization of actin in the lamellipodium reflects actin dynamics and is of critical importance for the mechanism of cell motility. In previous structural studies, the lamellipodial actin network was analyzed primarily by electron microscopy (EM). An understanding of lamellipodial organization would benefit significantly if the EM data were complemented and put… CONTINUE READING

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Mechanism of actin-based motility

  • D. Pantaloni, C. Le Clainche, M. F. Carlier
  • Science
  • 2001
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