Orientation-specific signalling by thrombopoietin receptor dimers.

@article{Staerk2011OrientationspecificSB,
  title={Orientation-specific signalling by thrombopoietin receptor dimers.},
  author={Judith Staerk and Jean-Philippe Defour and Christian Pecquet and Emilie Leroy and H{\'e}l{\`e}ne Antoine-Poirel and Ian C Brett and Miki Itaya and Steven Oliver Smith and William Vainchenker and Stefan N Constantinescu},
  journal={The EMBO journal},
  year={2011},
  volume={30 21},
  pages={
          4398-413
        }
}
Ligand binding to the thrombopoietin receptor is thought to stabilize an active receptor dimer that regulates megakaryocyte differentiation and platelet formation, as well as haematopoietic stem cell renewal. By fusing a dimeric coiled coil in all seven possible orientations to the thrombopoietin receptor transmembrane (TM)-cytoplasmic domains, we show that specific biological effects and in vivo phenotypes are imparted by distinct dimeric orientations, which can be visualized by cysteine… CONTINUE READING
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