Orientation-specific signalling by thrombopoietin receptor dimers.

  title={Orientation-specific signalling by thrombopoietin receptor dimers.},
  author={Judith Staerk and Jean-Philippe Defour and Christian Pecquet and Emilie Leroy and H{\'e}l{\`e}ne Antoine-Poirel and Ian C Brett and Miki Itaya and Steven Oliver Smith and William Vainchenker and Stefan N Constantinescu},
  journal={The EMBO journal},
  volume={30 21},
Ligand binding to the thrombopoietin receptor is thought to stabilize an active receptor dimer that regulates megakaryocyte differentiation and platelet formation, as well as haematopoietic stem cell renewal. By fusing a dimeric coiled coil in all seven possible orientations to the thrombopoietin receptor transmembrane (TM)-cytoplasmic domains, we show that specific biological effects and in vivo phenotypes are imparted by distinct dimeric orientations, which can be visualized by cysteine… CONTINUE READING
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Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.

Proceedings of the National Academy of Sciences of the United States of America • 2013
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