Orientation of heparin-binding sites in native vitronectin. Analyses of ligand binding to the primary glycosaminoglycan-binding site indicate that putative secondary sites are not functional.

@article{Gibson1999OrientationOH,
  title={Orientation of heparin-binding sites in native vitronectin. Analyses of ligand binding to the primary glycosaminoglycan-binding site indicate that putative secondary sites are not functional.},
  author={Adele Gibson and J A Lamerdin and Ping Zhuang and K Baburaj and Engin H Serpersu and Cynthia B. Peterson},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 10},
  pages={6432-42}
}
A primary heparin-binding site in vitronectin has been localized to a cluster of cationic residues near the C terminus of the protein. More recently, secondary binding sites have been proposed. In order to investigate whether the binding site originally identified on vitronectin functions as an exclusive and independent heparin-binding domain, solution binding methods have been used in combination with NMR and recombinant approaches to evaluate ligand binding to the primary site. Evaluation of… CONTINUE READING
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