Orientation dependence of trinucleotide CAG repeat instability in Saccharomyces cerevisiae.

@article{Maurer1996OrientationDO,
  title={Orientation dependence of trinucleotide CAG repeat instability in Saccharomyces cerevisiae.},
  author={Dr. Joachim Maurer and Brennon L O'Callaghan and Dennis M. Livingston},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 12},
  pages={6617-22}
}
To examine the chromosomal stability of repetitions of the trinucleotide CAG, we have cloned CAG repeat tracts onto the 3' end of the Saccharomyces cerevisiae ADE2 gene and placed the appended gene into the ARO2 locus of chromosome VII. Examination of chromosomal DNA from sibling colonies arising from clonal expansion of strains harboring repeat tracts showed that repeat tracts often change in length. Most changes in tract length are decreases, but rare increases also occur. Longer tracts are… CONTINUE READING

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