Orientation-conserved transfer of symmetric Krebs cycle intermediates in mammalian tissue.

@article{Sherry1994OrientationconservedTO,
  title={Orientation-conserved transfer of symmetric Krebs cycle intermediates in mammalian tissue.},
  author={A Dean Sherry and B Sumegi and Brandy Miller and Grant Cottam and S R Gavva and J. Gwynfryn Jones and Craig Malloy},
  journal={Biochemistry},
  year={1994},
  volume={33 20},
  pages={6268-75}
}
Metabolism of [2-13C]-, [3-13C]-, and [1,2,3-13C]propionate in perfused rat livers and [2-13C]-acetate in perfused rat hearts has been examined in tissue extracts by 13C NMR. Label from [2-13C]-propionate was preferentially incorporated into the C2 carbon of lactate, alanine, and aspartate in liver tissue while label from [3-13C]propionate appeared preferentially in the C3 carbon of those same molecules. These data suggest that 13C may not be completely randomized in the symmetric citric acid… CONTINUE READING

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