Orientation and polarity in collectively migrating cell structures: statics and dynamics.

@article{Reffay2011OrientationAP,
  title={Orientation and polarity in collectively migrating cell structures: statics and dynamics.},
  author={Myriam Reffay and Laurence Petitjean and Sylvie Coscoy and Erwan Grasland-Mongrain and François Amblard and Axel Buguin and Pascal Silberzan},
  journal={Biophysical journal},
  year={2011},
  volume={100 11},
  pages={2566-75}
}
Collective cell migration is often characterized by the spontaneous onset of multicellular protrusions (known as fingers) led by a single leader cell. Working with epithelial Madin-Darby canine kidney monolayers we show that cells within the fingers, as compared with the epithelium, are well oriented and polarized along the main finger direction, which suggests that these cells actively migrate. The cell orientation and polarity decrease continuously from the tip toward the epithelium over a… CONTINUE READING