Corpus ID: 201063461

Oridonin inhibits the proliferation, migration and invasion of human osteosarcoma cells via suppression of matrix metalloproteinase expression and STAT3 signalling pathway.

@article{Du2019OridoninIT,
  title={Oridonin inhibits the proliferation, migration and invasion of human osteosarcoma cells via suppression of matrix metalloproteinase expression and STAT3 signalling pathway.},
  author={Yiqun Du and J. Zhang and S. Yan and Z. Tao and Chenchen Wang and M. Huang and X. Zhang},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  year={2019},
  volume={24 3},
  pages={
          1175-1180
        }
}
  • Yiqun Du, J. Zhang, +4 authors X. Zhang
  • Published 2019
  • Chemistry, Medicine
  • Journal of B.U.ON. : official journal of the Balkan Union of Oncology
PURPOSE Oridonin, a diterpenoid, has been reported to exhibit anticancer activity against a wide range of cancer types.In this study, the effect Oridonin was examined against human osteosarcoma cells. METHODS The human osteosarcoma cells U2OS were treated with various concentrations of Oridonin from 0-200 μM for 24 h. The anti-proliferative effects of Oridonin were measured by cell viability assay. DAPI and annexin V/propidium iodide (PI) assays were employed to examine the induction of… Expand
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