Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

Abstract

Oridonin, a tetracycline diterpenoid compound, has the potential antitumor activities. Here, we evaluate the antitumor activity and action mechanisms of oridonin in colorectal cancer. Effects of oridonin on cell proliferation were determined by using a CCK-8 Kit. Cell cycle distribution was determined by flow cytometry. Apoptosis was examined by analyzing… (More)
DOI: 10.1186/1471-2407-10-610

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@inproceedings{Gao2009OridoninIA, title={Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc}, author={Feng-hou Gao and Xiao-Hui Hu and Wei Li and Hua Liu and Yan-Jie Zhang and Zhu-ying Guo and Mang-hua Xu and Shi-ting Wang and Bin Jiang and Feng Liu and Ying-zheng Zhao and Yong Fang and Fang-Yuan Chen and Ying-li Wu}, booktitle={BMC Cancer}, year={2009} }