Organotypic liver culture models: Meeting current challenges in toxicity testing

  title={Organotypic liver culture models: Meeting current challenges in toxicity testing},
  author={Edward L. Lecluyse and Rafal P. Witek and Melvin E. Andersen and Mark J. Powers},
  booktitle={Critical reviews in toxicology},
Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a significant challenge for the pharmaceutical and chemical industries. Generally, conventional in vitro hepatic model systems (i.e. 2-D static monocultures of primary or immortalized hepatocytes) are limited by their inability to maintain histotypic and phenotypic characteristics over time in culture, including stable expression of clearance and bioactivation pathways, as well as complex adaptive… CONTINUE READING


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