Organotypic cultures represent tumor microenvironment for drug testing


Currently there are no cancer models that can accurately predict the clinical activity of a drug. Compounds are screened and optimized for anticancer activity in a series of in vitro and in vivo models, each of which has its own strengths and limitations. Organotypic models are three-dimensional in vitro representations of tumor microenvironment, which are more biologically relevant and technically challenging than cytotoxicity, clonogenic and spheroid assays, but less in comparison to in vivo models.

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@inproceedings{Benbrook2006OrganotypicCR, title={Organotypic cultures represent tumor microenvironment for drug testing}, author={Doris Mangiaracina Benbrook and Nikolina Vlatkovi{\'c}}, year={2006} }