Organotin speciation and tissue distribution in rat dams, fetuses, and neonates following oral administration of tributyltin chloride.

@article{Cooke2008OrganotinSA,
  title={Organotin speciation and tissue distribution in rat dams, fetuses, and neonates following oral administration of tributyltin chloride.},
  author={Gerard M. Cooke and Don S Forsyth and Genevieve S. Bondy and Romain Tachon and Brett A Tague and Laurie C Coady},
  journal={Journal of toxicology and environmental health. Part A},
  year={2008},
  volume={71 6},
  pages={384-95}
}
Tributyltin (TBT) is a biocide that contaminates human foodstuffs, especially shellfish. TBT is an endocrine disrupter, producing imposex in several marine gastropods. Previous studies showed that oral dosing of rat dams with TBT chloride leads to abnormal fetal and postnatal development. In this study, the tissue distribution and speciation of organotins in tissues were examined in dams, fetuses, and neonates following dosing of rat dams commencing on gestational day (GD) 8 by oral gavage with… CONTINUE READING

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