Organosilicate-polymer drug delivery systems: controlled release and enhanced mechanical properties.

@article{Cypes2003OrganosilicatepolymerDD,
  title={Organosilicate-polymer drug delivery systems: controlled release and enhanced mechanical properties.},
  author={Stephen H Cypes and W. Mark Saltzman and Emmanuel P. Giannelis},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2003},
  volume={90 2},
  pages={163-9}
}
Dexamethasone-loaded poly(ethylene-co-vinyl acetate) (EVAc) nanocomposites were fabricated via solution-casting with three different organosilicates for study in a drug delivery system. X-ray diffraction (XRD) showed that all three nanocomposites were in an intercalated morphology. Release studies of dexamethasone into phosphate-buffered saline revealed that the presence of silicates reduced the rate of drug release, and this reduction was a function of volume fraction of silicate in the… CONTINUE READING

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