Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat.

@article{Busker1991OrganophosphatePA,
  title={Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat.},
  author={R. Busker and J. Zijlstra and H. J. van der Wiel and B. Melchers and H. V. van Helden},
  journal={Toxicology},
  year={1991},
  volume={69 3},
  pages={
          331-44
        }
}
A method was developed to study exclusively those therapeutic effects of oximes that are not related to reactivation of organophosphate-inhibited acetylcholinesterase (AChE). The model uses the organophosphorus compound crotylsarin (CRS), which proved to be a potent, irreversible, peripherally and centrally active AChE inhibitor with a very short biological half-life. CRS-inhibited AChE appeared to age very rapidly, because in vitro addition of oximes immediately following inhibition, did not… Expand
The value of novel oximes for treatment of poisoning by organophosphorus compounds.
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Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos.
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