Organophosphate-Induced Delayed Polyneuropathy

@article{Lotti2005OrganophosphateInducedDP,
  title={Organophosphate-Induced Delayed Polyneuropathy},
  author={Marcello Lotti and Angelo Moretto},
  journal={Toxicological Reviews},
  year={2005},
  volume={24},
  pages={37-49}
}
Organophosphate-induced delayed polyneuropathy (OPIDP) is a rare toxicity resulting from exposure to certain organophosphorus (OP) esters. It is characterised by distal degeneration of some axons of both the peripheral and central nervous systems occurring 1–4 weeks after single or short-term exposures. Cramping muscle pain in the lower limbs, distal numbness and paraesthesiae occur, followed by progressive weakness, depression of deep tendon reflexes in the lower limbs and, in severe cases, in… 
Organophosphate induced delayed polyneuropathy in man: An overview
TLDR
This review discusses OPIDP in man with emphasis on clinical presentation, pathogenesis, molecular mechanisms, and possibilities for prevention/therapy.
Peripheral Nervous System Effects and Delayed Neuropathy
TLDR
OPIDP is characterized by distal degeneration of long and large-diameter motor, and sensory axons of both peripheral nerves and spinal cord and can be elicited in the rat by very high single or repeated doses of neuropathic OPs.
Mechanisms for consideration for intervention in the development of organophosphorus-induced delayed neuropathy.
TLDR
Experimental attempts to prevent and/or treat organophosphorus-induced delayed neuropathy are summarized, but there is yet no single specific treatment available for use in clinical practice to prevent or alleviate the severe effects of OPIDN.
New insights into the organophosphate-induced intermediate syndrome
TLDR
An outstanding case of severe oral OP poisoning with intermediate syndrome developed on the fourth day after hospital admission, which is the first with such a spread of muscle weakness and provides new insights into the polymorphic clinical manifestations of acute OP poisoning.
Organophosphate induced delayed neuropathy after an acute cholinergic crisis in self-poisoning
TLDR
Peripheral nerve involvement is not uncommon after recovery from a cholinergic crisis in chlorpyrifos self-poisoning and debilitating in some patients, and Detection of subclinical injury on NCS may provide an early window to prevent severe symptomatic neuropathy.
Organophosphate-Induced Intermediate Syndrome
TLDR
The intermediate syndrome (IMS) following organophosphorus (OP) insecticide poisoning was first described in the mid-1980s and it is now emerging that the degree and extent of muscle weakness may vary following the onset of the IMS, whilst repetitive firing is observed during the acute cholinergic syndrome.
Organophosphorus and carbamate insecticide poisoning.
TLDR
The therapeutic combination of oxime, atropine, and diazepam is well established experimentally in the treatment of OP pesticide poisoning, however, there has been controversy as to whether oximes improve morbidity and mortality in human poisoning.
TRPA1 channel mediates organophosphate-induced delayed neuropathy
TLDR
It is demonstrated that TRPA1 channel (Transient receptor potential cation channel, member A1) mediates organophosphate-induced delayed neuropathy (OPIDN), and targeting TRPA 1 is an effective way for the treatment of OPIDN.
Flaccid paraplegia of organophosphate-induced delayed polyneuropathy leading to early spastic paraplegia. Case report
TLDR
The reported case demonstrates the myelopathic presentation of organophosphate-induced delayed polyneuropathy in a middle aged male patient with acute organophile compound poisoning who in turn had acute cholinergic crisis and was put on ventilator.
Organophosphorus-Induced Delayed Neuropathy
Publisher Summary OPIDN is a generally progressive, irreversible disorder that causes clinical manifestations appearing days to weeks after humans and certain species of animals are exposed to OP
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