Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead

@article{Iyengar2016OrganophosphateHydrolyzingEA,
  title={Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead},
  author={A. Iyengar and A. Pande},
  journal={The Protein Journal},
  year={2016},
  volume={35},
  pages={424-439}
}
Nerve agents (NAs) are extremely neurotoxic synthetic organophosphate (OP) compounds exploited as weapons of mass destruction in terrorist attacks and chemical warfare. Considering the current world scenario, there is a persistent threat of NA-exposure to military personals and civilians. Various prophylactic and post-exposure treatments (such as atropine and oximes) available currently for NA-poisoning are inadequate and unsatisfactory and suffer from severe limitations. Hence, developing safe… Expand
Theoretical study on the toxicity of ‘Novichok’ agent candidates
Advances in Enzyme-Based Biosensors for Pesticide Detection

References

SHOWING 1-10 OF 218 REFERENCES
Clinical Management of Organophosphorus Nerve Agents’ Poisonings
Developments in alternative treatments for organophosphate poisoning.
Bioscavengers for the protection of humans against organophosphate toxicity.
Chemical aspects of pharmacological prophylaxis against nerve agent poisoning.
Drug development for the management of organophosphorus poisoning
Organophosphorus hydrolase as an in vivo catalytic nerve agent bioscavenger.
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents
...
1
2
3
4
5
...