Organometallic photonucleases: a novel class of DNA-cleaving agents.

Abstract

The first demonstration of DNA cleavage by an organic radical generated via homolysis of a metal-alkyl bond in a Cp-metal complex is presented. Irradiation of CpW(CO)3CH3 (1.5 molecules/base pair) produced methyl radical, giving single-strand cleavage of pBR322 DNA. This process was inhibited by the general radical trap cysteine and by TEMPO, which traps… (More)

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Cite this paper

@article{Mohler1998OrganometallicPA, title={Organometallic photonucleases: a novel class of DNA-cleaving agents.}, author={Debra L. Mohler and D R Dain and Angela D. Kerekes and Walder Nadler and T L Scott}, journal={Bioorganic & medicinal chemistry letters}, year={1998}, volume={8 7}, pages={871-4} }