Organoids as an in vitro model of human development and disease

  title={Organoids as an in vitro model of human development and disease},
  author={A. Fatehullah and Si Hui Tan and N. Barker},
  journal={Nature Cell Biology},
  • A. Fatehullah, Si Hui Tan, N. Barker
  • Published 2016
  • Biology, Medicine
  • Nature Cell Biology
  • The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique. 
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