Organoids as an in vitro model of human development and disease

@article{Fatehullah2016OrganoidsAA,
  title={Organoids as an in vitro model of human development and disease},
  author={A Fatehullah and Si Hui Tan and Nick Barker},
  journal={Nature Cell Biology},
  year={2016},
  volume={18},
  pages={246-254}
}
The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique. 
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