Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

@article{Zheng2018OrganohalogensNB,
  title={Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.},
  author={Jing Zheng and Shaun M. K. McKinnie and Abrahim El Gamal and Wei Feng and Yao Dong and Vinayak Agarwal and William Fenical and Abdhesh Kumar and Zhengyu Cao and Bradley S. Moore and Isaac N. Pessah},
  journal={Environmental science \& technology},
  year={2018},
  volume={52 9},
  pages={
          5469-5478
        }
}
Contemporary sources of organohalogens produced as disinfection byproducts (DBPs) are receiving considerable attention as emerging pollutants because of their abundance, persistence, and potential to structurally mimic natural organohalogens produced by bacteria that serve signaling or toxicological functions in marine environments. Here, we tested 34 organohalogens from anthropogenic and marine sources to identify compounds active toward ryanodine receptor (RyR1), known toxicological targets… 
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12 Citations
Background Citations
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Methods Citations
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12 Citations

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Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase.

A catalytic mechanism is proposed for Bmp8 that is reminiscent of that catalyzed by human deiodinases in the maintenance of thyroid hormones, and the identification of the key catalytic residues enabled us to recognize divergent functional homologues of BMP8.

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Neurotoxicity of polychlorinated biphenyls and related organohalogens

The state of knowledge regarding outcomes across domains related to cognition, attention, behavioral regulation and executive function, and social behavior is described, including traits related to attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD).

Halogenated compound secreted by marine bacteria halts larval urchin development

Toxicity Assessment of Octachlorostyrene in Human Liver Carcinoma (HepG2) Cells

OCS is cytotoxic and can induce apoptosis, in which ROS and mitochondrial dysfunction play important roles; however, the observed increase in MMP appears to indicate that HepG2 is resistant to the toxicity induced by OCS.

Will climate change influence production and environmental pathways of halogenated natural products?

Review production, sources, distribution and transport pathways of nHCs and hHNPs through water and air, pointing out areas of commonality and argue that climate change may alter these factors for hHWNPs.

Insights into Thiotemplated Pyrrole Biosynthesis Gained from the Crystal Structure of Flavin-Dependent Oxidase in Complex with Carrier Protein.

This work presents the crystal structure of a flavin-dependent prolyl oxidase that furnishes thiotemplated pyrrole as the product, in complex with its cognate CP in the holo and product-bound states.

Genetic examination of the marine bacterium Pseudoalteromonas luteoviolacea and effects of its metamorphosis-inducing factors.

The results show that 9 of 19 sequenced P. luteoviolacea genomes genetically encode both MACs and TBP, which reveal a hidden complexity of interactions between a single bacterial species, the factors it produces and two species of larvae belonging to different phyla.

Promoting larval settlement of coral Pocillopora damicornis by calcium

This study suggests that applying Ca 2+ to effectively and efficiently induce coral larval settlement is viable for laboratory research and small-scale aquaculture systems, and it might become a useful tool in future coral reef restoration engineering.

References

SHOWING 1-10 OF 98 REFERENCES

Ortho-substituted polychlorinated biphenyls alter calcium regulation by a ryanodine receptor-mediated mechanism: structural specificity toward skeletal- and cardiac-type microsomal calcium release channels.

These results are the first to demonstrate a selective ryanodine receptor-mediated mechanism by which ortho-substituted PCBs alter microsomal Ca2+ transport and may have toxicological relevance.

Nontargeted Biomonitoring of Halogenated Organic Compounds in Two Ecotypes of Bottlenose Dolphins (Tursiops truncatus) from the Southern California Bight

This nontargeted analytical framework provided a comprehensive list of HOCs that may be characteristic of the region, and its application within monitoring surveys may suggest new chemicals for evaluation.

Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1).

A practical application of the receptor-based screen developed here with RyR1 is that it provides a quantitative SAR that may be useful in predicting biological activity and risk of mixtures containing noncoplanar PCB congeners that have low or a lack of aryl hydrocarbon receptor activity.

Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.

Naturally Occurring Organohalogen Compounds - A Comprehensive Update

Author's Note.- Introduction.- Origins: Marine Environment - Terrestrial Environment - Extraterrestrial Environment Occurrence: Simple Alkanes - Simple Functionalized Acyclic Organohalogens - Simple…

Nontargeted Screening of Halogenated Organic Compounds in Bottlenose Dolphins (Tursiops truncatus) from Rio de Janeiro, Brazil.

To catalog the diversity and abundance of halogenated organic compounds (HOCs) accumulating in high trophic marine species from the southwestern Atlantic Ocean, tissue from bottlenose dolphins…

Newly Identified DDT-Related Compounds Accumulating in Southern California Bottlenose Dolphins.

Quantitative analysis revealed that TCPM was the second most abundant compound class detected in the blubber, following DDE, and TCPMOH loads were greater than DDT, suggesting that transformation products contribute to the majority of the load of DDT-related contaminants in these sentinels of ocean health.

Halopyrroles: a new group of highly toxic disinfection byproducts formed in chlorinated saline wastewater.

This DBP showed significantly higher developmental toxicity than any of the haloaliphatic and haloaromatic DBPs previously tested and was successfully solved by diluting the pretreated samples.

Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish.

Radiocarbon evidence for a naturally produced, bioaccumulating halogenated organic compound.

The presence of detectable 14C in the DBP-Br4Cl2 strongly points to at least a natural or biogenic source, however, these delta14C values for DBPs are more depleted than expected for a recently synthesized natural product.
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