Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

  title={Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.},
  author={Jing Zheng and Shaun M. K. McKinnie and Abrahim El Gamal and Wei Feng and Yao Dong and Vinayak Agarwal and William Fenical and Abdhesh Kumar and Zhengyu Cao and Bradley S. Moore and Isaac N. Pessah},
  journal={Environmental science \& technology},
  volume={52 9},
Contemporary sources of organohalogens produced as disinfection byproducts (DBPs) are receiving considerable attention as emerging pollutants because of their abundance, persistence, and potential to structurally mimic natural organohalogens produced by bacteria that serve signaling or toxicological functions in marine environments. Here, we tested 34 organohalogens from anthropogenic and marine sources to identify compounds active toward ryanodine receptor (RyR1), known toxicological targets… 

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Neurotoxicity of polychlorinated biphenyls and related organohalogens

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