Organofluorine inhibitors of amyloid fibrillogenesis.

@article{Toeroek2006OrganofluorineIO,
  title={Organofluorine inhibitors of amyloid fibrillogenesis.},
  author={Marianna Toeroek and Mohammed Abid and Shilpa C. Mhadgut and Bela Toeroek},
  journal={Biochemistry},
  year={2006},
  volume={45 16},
  pages={
          5377-83
        }
}
  • Marianna Toeroek, Mohammed Abid, +1 author Bela Toeroek
  • Published in Biochemistry 2006
  • Chemistry, Medicine
  • The design and application of an effective, new class of organofluorine inhibitors of amyloid fibrillogenesis are described. Based on experimental evidence a core structure containing indol-3-yl, trifluoromethyl, hydroxyl, and carboxylic acid ester functions has been designed. Several substituted derivatives of this core structure have been synthesized, using various indole derivatives. While all inhibitor candidates have shown considerable effect (20-70% inhibition) in structure-activity… CONTINUE READING

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