Organofluorine chemistry

  title={Organofluorine chemistry},
  author={Graham Sandford},
  journal={Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences},
  pages={455 - 471}
  • G. Sandford
  • Published 9 January 2021
  • Chemistry
  • Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences
The fascination of organofluorine chemistry stems from the fact that, apart from a few exceptions, molecules containing carbon–fluorine bonds do not occur in nature and so the field is entirely ‘man–made’. Many fluoro–organic molecules are encountered by the general public on a daily basis, but this is probably not widely recognized even by the scientific community. For example, the chlorofluorocarbon (CFC) refrigerants, now being replaced by the ozone–friendly hydrofluorocarbons (HFC), are… 
Per- and polyfluoroalkyl substances in the environment
Over the past several years, the term PFAS (per- and polyfluoroalkyl substances) has grown to be emblematic of environmental contamination, garnering public, scientific, and regulatory concern. PFAS
Photosensitized direct C–H fluorination and trifluoromethylation in organic synthesis
This review highlights photosensitized C–H fluorination as a recent strategy for the direct and remote activation of C-H (especially C(sp3)–H) bonds and presents the developing mechanistic understandings of these reactions and exemplify concepts to assist the future planning of reactions.
Selective fluoroalkylation of organic compounds by tackling the "negative fluorine effect".
By tackling the NFE, the research group has attempted to design nucleophilic fluoroalkylation reactions with fluorinated sulfones and related reagents as four methods to modulate the fluoroalkylation reactions.
Crystal structure and mechanism of a bacterial fluorinating enzyme
The sequence and three-dimensional structure of the first native fluorination enzyme, 5′-fluoro-5′-deoxyadenosine synthase, from Streptomyces cattleya is reported, and a nucleophilic substitution mechanism for this biological fluorination reaction is proposed.
A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates
A synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosaccharides stereoselectively is reported, which shows the relative stereochemistry of multi-vicinal fluorine atoms has a strong effect on the lipophilicities (logP).
Synthesis of bioactive fluoropyrrolidines via copper(i)-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides
An efficient route to obtain enantioenriched 3, 3-difluoro- and 3,3,4-trifluoropyrrolidinyl derivatives by Cu(i)-catalysed enantioselective 1,3-dipolar cycloaddition of azomethine ylides with less active 1,1,2-trIfluorostyrenes is reported.
Flow microreactor synthesis in organo-fluorine chemistry
This review outlines the successful examples of synthesis and reactions of fluorine-containing molecules by the use of flow microreactor systems to overcome long-standing problems in fluorine chemistry.
Zürich Statement on Future Actions on Per- and Polyfluoroalkyl Substances (PFASs)
A group of more than 50 international scientists and regulators held a two-day workshop in November, 2017 that identified both the respective needs of and common goals shared by the scientific and policy communities, made recommendations for cooperative actions, and outlined how the science–policy interface regarding PFASs can be strengthened using new approaches for assessing and managing highly persistent chemicals.
Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation
This approach focuses exclusively on transition metal-catalyzed reactions that allow the introduction of –CFH2, –CF2H, –CnF2 n +1 and –SCF3 groups onto sp² carbon atoms.
Nafion®-H Catalyzed Synthesis of Fluorinated Benzimidazolines, Benzothiazolines, Benzoxazolines and Dihydrobenzoxazinones.
SYNTHESIS 2008, No. 6, pp 0897–0902xx.xx.2008 Advanced online publication: 18.02.2008 DOI: 10.1055/s-2008-1032182; Art ID: M08807SS © Georg Thieme Verlag Stuttgart · New York Abstract: Nafion-H, a


Survival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric Pressure
Investigation of organic fluid respiration may lead to development of a safe method to support the respiration of man by liquids equilibrated with gases at atmospheric pressure.
The renewed challenge of antibacterial chemotherapy
The background to this situation, the evolution of the various antibacterial classes and of the current approaches being adopted to keep at bay the threat of a return to a pre-antibiotic era are examined.
Stratospheric ozone depletion
  • S. Lloyd
  • Environmental Science
    The Lancet
  • 1993
Special agents
Stable per ° uorinated carbanions
  • 1988
Stable tert - per ° uoroalkyl radicals by addition of ° uorine or tri ° uoromethyl to a per ° uo - roalkene
  • J . Am . Chem . Soc .
  • 1985
Alkylation and decarboxylation of ethyl 2 - ° uoro - 3 - oxobutanoate as a route to functionalised - ° uoroketones Tetrahedron
  • 1998