Organochlorines, p53 mutations in relation to breast cancer risk and survival. A Danish cohort-nested case-controls study

@article{Hyer2002OrganochlorinesPM,
  title={Organochlorines, p53 mutations in relation to breast cancer risk and survival. A Danish cohort-nested case-controls study},
  author={Annette Pernille H\oyer and A. -M. Gerdes and Torben J\orgensen and Fritz Rank and Helle B\oggild Hartvig},
  journal={Breast Cancer Research and Treatment},
  year={2002},
  volume={71},
  pages={59-65}
}
Epidemiological studies integrating genetic susceptibility with biological measurements of organochlorine exposure may provide new clues regarding these substances influence on breast cancer etiology. Initial attempts pursuing this avenue has dealt with polymorphisms in the carcinogen-metabolizing enzymes cytochrome P450 (CYPlAl). This study examined if mutations in the tumor suppressor gene p53 affected organochlorine exposure related breast cancer risk and survival. The material consisted of… CONTINUE READING