Organocatalytic oxidation of aldehydes to mixed anhydrides.


TEMPO catalyzes the direct oxidation of aldehydes to mixed anhydrides in the presence of a carboxylic acid. The anhydrides can be converted in situ to esters, secondary, tertiary or Weinreb amides in high yield. Oxidation of the aldehyde directly to 2-propyl esters is also possible using only catalytic amounts of acid. The oxidation reactions are rapid and take place under mild conditions.

DOI: 10.1039/c2cc35220f

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@article{Toledo2013OrganocatalyticOO, title={Organocatalytic oxidation of aldehydes to mixed anhydrides.}, author={Hila Toledo and Evgeni Pisarevsky and Adi Abramovich and Alex M Szpilman}, journal={Chemical communications}, year={2013}, volume={49 39}, pages={4367-9} }