Organocatalytic enantioselective synthesis of highly functionalized polysubstituted pyrrolidines.

Abstract

The organocatalytic conjugate addition of different aldehydes to beta-nitroacrolein dimethyl acetal, generating the corresponding highly functionalized nitroaldehydes in high yields and with high stereoselectivities, has been studied in detail. These transformations have been achieved by using both readily available starting materials in a 1:1 ratio as well… (More)
DOI: 10.1002/chem.200800788

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