Organocatalytic asymmetric domino Michael-Henry reaction for the synthesis of substituted bicyclo[3.2.1]octan-2-ones.

@article{Tsakos2013OrganocatalyticAD,
  title={Organocatalytic asymmetric domino Michael-Henry reaction for the synthesis of substituted bicyclo[3.2.1]octan-2-ones.},
  author={Michail Tsakos and Mark R J Elsegood and Christoforos G Kokotos},
  journal={Chemical communications},
  year={2013},
  volume={49 22},
  pages={2219-21}
}
The first organocatalytic asymmetric reaction between 1,4-cyclohexanedione and nitroalkenes has been studied, affording bicyclo[3.2.1]octane derivatives containing four continuous stereogenic centres. The products were obtained through a domino Michael-Henry process as a single diastereoisomer with excellent enantioselectivities. 

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