Organocatalytic asymmetric conjugate addition and cascade acyl transfer reaction of α-nitroketones.

Abstract

Organocatalytic asymmetric conjugate addition of α-nitroketones to β,γ-unsaturated α-keto esters has been developed. A pyrrolidine-based thiourea-tertiary amine was identified as the best catalyst. The reaction was found to proceed via cascade conjugate addition and acyl transfer reaction. A number of α-nitroketones and β,γ-unsaturated α-keto esters were… (More)
DOI: 10.1021/jo2009752

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