Organocatalytic and highly enantioselective direct alpha-amination of aromatic ketones.

Abstract

The first highly enantioselective direct alpha-amination of aryl ketones was reported to be catalyzed by organic primary amines derived from cinchona alkaloids. Excellent enantioselectivities (88-99% ee) have been achieved for a broad spectrum of aryl ketones. The presence of 4 A molecular sieves was of great assistance for the high conversions and enantiocontrol.

Cite this paper

@article{Liu2007OrganocatalyticAH, title={Organocatalytic and highly enantioselective direct alpha-amination of aromatic ketones.}, author={Tian-Yu Liu and Hai-Lei Cui and Yan Zhang and Kun Jiang and Wei Du and Zhao-Quan He and Ying-Chun Chen}, journal={Organic letters}, year={2007}, volume={9 18}, pages={3671-4} }