Organocatalytic Enantioselective Amination of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral α-Hydrazino Esters.

Abstract

An efficient enantioselective α-amination of 2-substituted 3-indolinones has been achieved for the first time using hydroquinidine as a chiral catalyst through an aza-Michael reaction. The desired α-hydrazino esters are obtained in excellent yields with high enantiomeric excess leading to a quaternary stereocenter with a broad substrate scope.

DOI: 10.1021/acs.orglett.6b03473

Cite this paper

@article{Yarlagadda2017OrganocatalyticEA, title={Organocatalytic Enantioselective Amination of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral α-Hydrazino Esters.}, author={Suresh Yarlagadda and Balu Ramesh and C Ravikumar Reddy and Laxmi Srinivas and Balasubramanian Sridhar and Basi V Subba Reddy}, journal={Organic letters}, year={2017}, volume={19 1}, pages={170-173} }