Organocatalytic Asymmetric Michael/Hemiketalization/Retro-aldol Reaction of α-Nitroketones with Unsaturated Pyrazolones: Synthesis of 3-Acyloxy Pyrazoles.

Abstract

An organocatalytic asymmetric cascade Michael/hemiketalization/retro-aldol reaction between unsaturated pyrazolones and α-nitroketones is described. A bifunctional thiourea catalyst was found to be efficient for this reaction. With 10 mol % of catalyst, high yields as well as excellent enantioselectivities are attained for a variety of 3-acyloxy pyrazoles… (More)
DOI: 10.1021/acs.orglett.6b03823

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@article{Maity2017OrganocatalyticAM, title={Organocatalytic Asymmetric Michael/Hemiketalization/Retro-aldol Reaction of α-Nitroketones with Unsaturated Pyrazolones: Synthesis of 3-Acyloxy Pyrazoles.}, author={Rajendra Maity and Chandan Gharui and Arun K Sil and Subhas Chandra Pan}, journal={Organic letters}, year={2017}, volume={19 3}, pages={662-665} }