Organizing axes in time and space; 25 years of colinear tinkering.

  title={Organizing axes in time and space; 25 years of colinear tinkering.},
  author={Marie Kmita and Denis Duboule},
  volume={301 5631},
During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the "Hox clock"). Recent advances in the knowledge of the underlying mechanisms reveal that the embryo uses a variety of strategies to implement this colinear process, depending on both the type and the evolutionary history of axial structures. The search for a universal mechanism has likely hampered our… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 219 extracted citations

Conserved cluster organization of insect Runx genes

Development Genes and Evolution • 2008
View 3 Excerpts
Highly Influenced

Hox genes are not always Colinear

International journal of biological sciences • 2006
View 4 Excerpts
Highly Influenced

The molecular setup of the avian head mesoderm and its implication for craniofacial myogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists • 2006
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…