Organizing axes in time and space; 25 years of colinear tinkering.

@article{Kmita2003OrganizingAI,
  title={Organizing axes in time and space; 25 years of colinear tinkering.},
  author={Marie Kmita and Denis Duboule},
  journal={Science},
  year={2003},
  volume={301 5631},
  pages={331-3}
}
During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the "Hox clock"). Recent advances in the knowledge of the underlying mechanisms reveal that the embryo uses a variety of strategies to implement this colinear process, depending on both the type and the evolutionary history of axial structures. The search for a universal mechanism has likely hampered our… CONTINUE READING
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