Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large.

@article{Hough1997OrganizingAF,
  title={Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large.},
  author={Colleen Hough and Daniel F. Woods and Sun-mi Park and Peter J. Bryant},
  journal={Genes & development},
  year={1997},
  volume={11 23},
  pages={
          3242-53
        }
}
Discs large (Dlg) was the first identified member of an increasingly important class of proteins called membrane-associated guanylate kinase homologs (MAGUKs), which are often concentrated at cell junctions and contain distinct peptide domains named PDZ1-3, SH3, HOOK, and GUK. Dlg is localized at and required for the formation of both septate junctions in epithelial cells and synaptic junctions in neurons. In the absence of Dlg, epithelia lose their organization and overgrow. We tested the… CONTINUE READING

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Genetic transformation of Drosophila with transposable element vectors

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