Organizing Axes in Time and Space; 25 Years of Colinear Tinkering

@article{Kmita2003OrganizingAI,
  title={Organizing Axes in Time and Space; 25 Years of Colinear Tinkering},
  author={Marie Kmita and Denis Duboule},
  journal={Science},
  year={2003},
  volume={301},
  pages={331 - 333}
}
During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the “Hox clock”). Recent advances in the knowledge of the underlying mechanisms reveal that the embryo uses a variety of strategies to implement this colinear process, depending on both the type and the evolutionary history of axial structures. The search for a universal mechanism has likely hampered our… 
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Hox genes in time and space during vertebrate body formation
TLDR
The regulation and possible role of collinear Hox gene activation during body formation is discussed and the direct role of Hox genes in controlling cellular movements during gastrulation is highlighted, therefore contributing to body formation.
Structure, function and evolution of topologically associating domains (TADs) atHOX loci
A Regulatory Archipelago Controls Hox Genes Transcription in Digits
Developmental regulation of the Hox genes during axial morphogenesis in the mouse
TLDR
This review aims to bring together recent findings that have advanced the understanding of the regulation of the Hox genes during mouse embryonic development and highlights the integration of these transducers of anteroposterior positional information into the genetic network that drives tissue generation and patterning during axial elongation.
Evo-devo: Relaxed constraints on Hox gene clustering during evolution
A new study of Hox genes in Oikopleura reveals these developmental genes to be scattered across the genome, rather than clustered, as found in most animals. Hox genes were initially identified in…
Global control regions and regulatory landscapes in vertebrate development and evolution.
Uncoupling Time and Space in the Collinear Regulation of Hox Genes
TLDR
It is shown that both positive and negative regulatory influences, located on either side of the cluster, control an early phase of collinear expression in the trunk, indicating that the mechanism underlying temporalCollinearity is distinct from those acting during the second phase.
The genesis and evolution of homeobox gene clusters
TLDR
Comparative genomics studies indicate that the more recently discovered ParaHox and NK clusters were linked to the Hox cluster early in evolution, and that together they constituted a 'megacluster' of homeobox genes that conspicuously contributed to body-plan evolution.
Changes in Hox genes’ structure and function during the evolution of the squamate body plan
TLDR
The genomic organization of Hox clusters in different reptiles and show that squamates have accumulated unusually large numbers of transposable elements at these loci, reflecting extensive genomic rearrangements of coding and non-coding regulatory regions.
Landscapes and archipelagos: spatial organization of gene regulation in vertebrates.
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References

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TLDR
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